Three adults and a 7-year-old child were killed, said Ohio State Patrol Sgt. Stan Jordan. Two other children were critically injured.
Joshua Nkansah, 40, of Fairfield was driving his minivan southbound in the northbound lanes of Interstate 75 near Franklin when he struck another minivan head-on about 2:30 a.m. Sunday morning. He and his 7-year-old son, David, died at the scene.
Another child in the car was taken to Atrium Hospital, then flown to Children's Hospital with life-threatening injuries, reports CBS Affiliate WKRC.
The minivan Nkansah struck was driven by Michele Barhorst from Madisonville, Tenn., who also died at the scene. Her husband, Scott Barhorst, was flown to University of Cincinnati Medical Center, where he later died.
The Barhorsts also had four of their children - ages 8, 9, 11 and 18 - in the minivan with them. They were taken to Dayton Children's Hospital and Atrium Hospital.
The crash is still under investigation, though alcohol was a suspected factor. Sgt. Jordan said investigators smelled liquor in the minivan that was going the wrong way and found a bottle of alcohol in the vehicle.