Emergency crews responded to the wreck on CR 7900, just off Highway 87, around 5:50 Friday afternoon.
When they arrived, they found the driver of the pickup truck had been ejected from the car.
The driver, 37-year-old San Juana Hernandez of Lubbock, was pronounced dead on scene.
Troopers say the woman and her two sons--ages 14 and 8 months old--were driving down the road when their car swerved into a ditch. That's when, troopers say, Hernandez over corrected and flipped the car.
Hernandez' two sons were taken to the hospital with non-life threatening injuries.
The speed limit on CR 7900 is 60 mph.
Stay with EverythingLubbock.com, KAMC and KLBK News for more as this story develops.