The Sooners started strong when Landry Jones found Justin Brown in the end zone to make it 7-0.
But Tech answered. Darrin Moore made a pivotal catch to get Tech inside the 10-yard line and Kenny Williams punctuated the drive with a 7-yard touchdown run.
The Red Raiders took their only lead of the game in the second quarter on a 35-yard field goal from Ryan Bustin.
It didn't last long. Blake Bell ran in from 1 yard out to give the Sooners a 14-10 lead.
And OU kept pouring it on in the second frame with a Kenny Stills touchdown grab from Jones giving the Sooners a 21-13 lead. Jones finished with 259 yards and two touchdowns in the game.
Oklahoma also owned the second half, forcing a turnover on downs on the initial Tech possession and cashing in the turnover for a Bell touchdown.
Seth Doege had one of his three interceptions returned 46 yards for a touchdown by Javon Harris in the third quarter to put the Sooners up 25. All in all, OU scored 27 straight.
But the Red Raiders remain optimistic.