Gen. Farzad Esmaili, head of Iran's air defense headquarters, says the drill will include Iranian jet fighters, drones, air defense systems and about 8,000 troops.
Esmaili is quoted by the official IRNA news agency on Thursday as saying that the area of the war games will cover nearly the entire eastern half of Iran. The exercise is to start on Saturday and last seven days.
The maneuvers come amid escalating tensions between Iran and the West over Tehran's suspect nuclear program, which the West fears is a cover for a pursuit of nuclear weapons. Iran denies the charge, saying the program is for peaceful purposes only.