The Lubbock Fire Department says it happened just after 11 p.m. at 2419 28th. Neighbors called in the fire after seeing flames.
The fire department says one was home at the time of the fire, three of the roommates were already out of town for spring break.
Fire crews on scene believe the fire started in the bedrooms at the back of the house and say it was unintentional.
The college home is destroyed and the fire department says it is not liveable.